High Fructose Corn Syrup Makes You Stupid

"Our findings illustrate that what you eat affects how you think," study researcher Fernando Gomez-Pinilla, of the University of California, Los Angeles, said in a statement. "Eating a high-fructose diet over the long term alters your brain's ability to learn and remember information. But adding omega-3 fatty acids to your meals can help minimize the damage."

The study was published in the May 15 issue of the Journal of Physiology. The research was done on rats, but the researchers believe their brain chemistry is similar enough to humans to extend the findings.

Sugar v. syrup

The researchers zeroed in on high-fructose corn syrup, an inexpensive liquid six times sweeter than cane sugar, that is commonly added to processed foods, including soft drinks, condiments, applesauce and baby food.

The average American consumes more than 40 pounds of high-fructose corn syrup per year, according to the U.S. Department of Agriculture. Some scientists even think sugar should be taxed the way alcohol and tobacco products are.

"We're not talking about naturally occurring fructose in fruits, which also contain important antioxidants," Gomez-Pinilla said. "We're concerned about high-fructose corn syrup that is added to manufactured food products as a sweetener and preservative."

Maze & Memory

Before starting the experimental diet the rats were taught to navigate their way through a maze using visual landmarks to remember the way.

The researchers then separated the rats into two groups, both consumed a fructose solution as their water, but one half of the rats also received omega-3 fatty acids, which are thought to protect against damage to the synapses — the chemical connections between brain cells that enable memory and learning. After six weeks of their new diet, the researchers tested the rats' recall of the maze route.

"The second group of rats navigated the maze much faster than the rats that did not receive omega-3 fatty acids," Gomez-Pinilla said. "Their brains showed a decline in synaptic activity. Their brain cells had trouble signaling each other, disrupting the rats' ability to think clearly and recall the route they'd learned six weeks earlier."

Sugar problems

The rats fed only high fructose corn syrup developed insulin resistance, which the researchers think may be what's hurting the brain cells.

Insulin resistance due to the constant flow of fructose may have changed how cells use and store sugar and use it as the energy required for processing thoughts and emotions. (sugar is the only fuel that brain cells know how to use.) If the brain cells can't use insulin correctly, it could impact how they work.

"Insulin is important in the body for controlling blood sugar, but it may play a different role in the brain, where insulin appears to disturb memory and learning," Gomez-Pinilla said. "Our study shows that a high-fructose diet harms the brain as well as the body. This is something new."

Their study also suggests that omega-3 fatty acids may help protect or heal the brain from this damage, Gomez-Pinilla said, though researchers aren't sure how either of these effects happen at the molecular level in the brain. He recommends taking one gram of omega-3 fatty acids per day.