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Omega-3 and Vascular Disease

by Pat Robinson

Omega 3 fatty acids improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity.

  • Omega-3 in modest doses reduces cardiac deaths, and in high doses reduces nonfatal cardiovascular events.
  • Dietary supplementation with omega-3 fatty acids reduces the incidence of sudden cardiac death in patients with myocardial infarction.
  • Omega-3 fatty acid reduce the total mortality and sudden death in patients with left ventricular systolic dysfunction.
  • Raising blood levels of omega-3 fatty acid levels may be 8 times effective than distributing automated external defibrillators (AEDs), and 2 times more effective than implanting implanting cardioverter defibrillators (ICDs) in preventing sudden death
  • Omega-3 fatty acid supplementation reduces total mortality and sudden death in patients who have already had a heart attack.
  • Consuming small quantities of fish is associated with a reduction in coronary heart disease.
  • Omega-3 fatty acids and vitamin D supplementation results in a substantial reduction in coronary calcium scores and slowed plaque growth.
  • Omega-3 fatty acids improve macro- and microvascular function in subjects with type 2 diabetes mellitus.
  • Fish oil improves tubular dysfunction, lipid profiles and oxidative stress in patients with IgA nephropathy.
  • In patients with stable coronary artery disease, an independent and inverse association exists between n-3 fatty acid levels and inflammatory biomarkers.
  • Omega-3 fatty acids improve endothelial function in peripheral arterial disease.
  • Fish oil has a beneficial effect on blood viscosity in peripheral vascular disease.
  • Fish oil supplementation improves walking distance in peripheral arterial disease.
  • The omega-3 fatty acid docosapentaenoic acid (DPA)reduces the risk of peripheral arterial disease associated with smoking.
  • Fish and long-chain omega-3 fatty acid intake reduce the risk of coronary heart disease and total mortality in diabetic women.
  • Higher plasma concentrations of EPA and DPA are associated with a lower risk of nonfatal myocardial infarction among women.
  • Omega-3 fatty acid consumption is inversely associated with incidence of hypertension.
  • Fish oil, but not flaxseed oil, decreases inflammation and prevents pressure overload-induced cardiac dysfunction.
  • The consumption of fish reduces the risk of ischemic stroke in elderly individuals.
  • Fish consumption reduces the risk of ischemic stroke in men.
  • Eicosapentaenoic acid (EPA) may have a therapeutic role in attenuating pulmonary hypertension.

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